Guanylic Acid E626
nucleotide_umami — Primarily natural_or_synthetic.
Guanosine-5'-monophosphate
CAS: 85-32-5
Factual Regulatory Reference
This database provides factual regulatory information compiled from official government sources. It does not constitute medical, nutritional, or safety advice. Regulatory status varies by country and is subject to change. Always refer to your local regulatory authority for the most current information.
What Is Guanylic Acid?
Guanylic acid (5'-guanylic acid, GMP) is a nucleotide flavor enhancer that synergizes strongly with glutamates to produce intense umami taste at much lower concentrations than glutamates alone. It occurs naturally in dried mushrooms, dried fish, and yeast extracts. The GMP + MSG combination produces a synergistic umami effect that is approximately 30–40 times more potent than MSG alone. JECFA considers it acceptable with no ADI specified. EFSA reviewed nucleotide flavor enhancers and confirmed safety. Approved globally.
? Did You Know?
Guanylic Acid occurs naturally in Mushrooms (especially shiitake) and Dried fish. Many people consume it daily without realizing it's also a listed food additive.
Guanylic Acid isn't just a food additive — it's also used in medicine.
In the EU, Guanylic Acid has a "quantum satis" authorization — Latin for "as much as needed." This means there's no specific maximum limit; manufacturers use only what's technologically necessary.
Detailed Regulatory Assessment
United States (FDA)
Generally recognized as safe
Japan (MHLW)
Compliant with Japanese food sanitation law.
Acceptable Daily Intake (ADI)
International Standard (JECFA)
mg/kg body weight per day
European Standard (EFSA)
Everyday Perspective
For a 60kg adult, this limit is roughly equivalent to consuming:
Natural Occurrence
A nucleotide that provides intense umami flavor. Synergistic with glutamates, multiplying umami taste intensity up to 8-fold when combined.
Manufacturing
Produced by enzymatic degradation of RNA from yeast or fish, or extracted from dried mushrooms.
Applications Beyond Food
Nutritional supplement, research reagent