flavor_enhancer INS 627

Disodium Guanylate E627

nucleotide_umami — Primarily natural_or_synthetic.

🇪🇺 EU: Approved

🇺🇸 USA: Approved

🇯🇵 Japan: Approved

🇦🇺 AU/NZ: Approved

🇨🇦 Canada: Approved

Scientific Name

Disodium 5'-guanylate

CAS: 5550-12-9

Data verified: 2026-04-04

Factual Regulatory Reference

This database provides factual regulatory information compiled from official government sources. It does not constitute medical, nutritional, or safety advice. Regulatory status varies by country and is subject to change. Always refer to your local regulatory authority for the most current information.

What Is Disodium Guanylate?

Disodium guanylate (sodium 5'-guanylate) is the sodium salt form of guanylic acid (E626), one of the most commonly used nucleotide flavor enhancers in the food industry. Used in combination with MSG (E621) or naturally occurring glutamates in instant noodles, chips, soups, and savory snacks. The synergistic enhancement of umami allows lower total flavor enhancer usage. JECFA considers it acceptable with no ADI specified. EFSA confirmed safety. Approved in EU, USA, Japan, Canada, and Australia. Often listed simply as 'disodium guanylate' on product labels.

? Did You Know?

Disodium Guanylate occurs naturally in Dried mushrooms (especially shiitake) and Seaweed. Many people consume it daily without realizing it's also a listed food additive.

Disodium Guanylate is produced through fermentation — the same biological process used to make bread, beer, and yogurt.

In the EU, Disodium Guanylate has a "quantum satis" authorization — Latin for "as much as needed." This means there's no specific maximum limit; manufacturers use only what's technologically necessary.

Detailed Regulatory Assessment

🇪🇺

European Union (EFSA)

approved Max: quantum satis mg/kg

None

Official EFSA Link

🇺🇸

United States (FDA)

approved GRAS

Generally recognized as safe

🇯🇵

Japan (MHLW)

approved Cat: 既存添加物

Compliant with Japanese food sanitation law.

Acceptable Daily Intake (ADI)

International Standard (JECFA)

Not specified (ADI not limited)

mg/kg body weight per day

European Standard (EFSA)

Not specified

Everyday Perspective

For a 60kg adult, this limit is roughly equivalent to consuming:

Natural Occurrence

The sodium salt of guanylic acid, providing intense umami flavor. Often combined with MSG and disodium inosinate (E631) to create powerful flavor synergy.

Dried mushrooms (especially shiitake)SeaweedDried fish

Manufacturing

Method: enzymatic degradation or fermentation

Produced by enzymatic degradation of RNA from yeast, bacteria, or fish. Can also be produced by microbial fermentation.

Frequently Asked Questions

What is Disodium Guanylate (E627)?

Disodium Guanylate (E627) is a flavor_enhancer used in food products. It is nucleotide_umami and natural_or_synthetic. The sodium salt of guanylic acid, providing intense umami flavor. Often combined with MSG and disodium inosinate (E631) to create powerful flavor synergy.

Where is Disodium Guanylate found naturally?

Disodium Guanylate is naturally found in Dried mushrooms (especially shiitake), Seaweed, Dried fish. The sodium salt of guanylic acid, providing intense umami flavor. Often combined with MSG and disodium inosinate (E631) to create powerful flavor synergy.

What is the ADI for Disodium Guanylate?

The Acceptable Daily Intake (ADI) for Disodium Guanylate is Not specified (ADI not limited) as established by JECFA (Joint FAO/WHO Expert Committee on Food Additives). ADI represents the amount that can be consumed daily over a lifetime without appreciable health risk.

What foods contain Disodium Guanylate?

Disodium Guanylate is used in various food categories including Salts, spices, soups, sauces, salads and protein products. It is used as a flavor_enhancer in these products.

Is Disodium Guanylate the same as Disodium 5'-GMP?

Yes, Disodium Guanylate is also known as Disodium 5'-GMP, Sodium guanylate, GMP. These are different names for the same substance.