Calcium Inosinate E633
nucleotide_umami — Primarily synthetic.
Calcium 5'-inosinate
CAS: 6106-04-3
Factual Regulatory Reference
This database provides factual regulatory information compiled from official government sources. It does not constitute medical, nutritional, or safety advice. Regulatory status varies by country and is subject to change. Always refer to your local regulatory authority for the most current information.
What Is Calcium Inosinate?
Calcium inosinate is the calcium salt of inosinic acid, used as a flavor enhancer. It provides nucleotide-based umami synergy while contributing calcium rather than sodium. JECFA considers it acceptable with no ADI specified. EFSA confirmed safety in its flavor enhancer review. Approved in the EU and other jurisdictions. Calcium inosinate is less commonly used in industrial formulations than disodium inosinate (E631), but has a role in specialized reduced-sodium product development.
? Did You Know?
In the EU, Calcium Inosinate has a "quantum satis" authorization — Latin for "as much as needed." This means there's no specific maximum limit; manufacturers use only what's technologically necessary.
Detailed Regulatory Assessment
United States (FDA)
Generally recognized as safe
Japan (MHLW)
Compliant with Japanese food sanitation law.
Acceptable Daily Intake (ADI)
International Standard (JECFA)
mg/kg body weight per day
European Standard (EFSA)
Everyday Perspective
For a 60kg adult, this limit is roughly equivalent to consuming:
Natural Occurrence
This additive is not known to occur naturally in significant quantities.
Manufacturing
Produced by enzymatic degradation of RNA and neutralization with calcium hydroxide.