sweetener INS 969

Advantame E969

artificial — Primarily synthetic.

🇪🇺 EU: Approved

🇺🇸 USA: Approved

🇯🇵 Japan: Approved

🇦🇺 AU/NZ: Approved

🇨🇦 Canada: Approved

Scientific Name

N-[3-(3-Hydroxy-4-methoxyphenyl)propyl]-L-α-aspartyl]-L-phenylalanine 1-methyl ester

CAS: 714229-20-6

Data verified: 2026-04-04

Factual Regulatory Reference

This database provides factual regulatory information compiled from official government sources. It does not constitute medical, nutritional, or safety advice. Regulatory status varies by country and is subject to change. Always refer to your local regulatory authority for the most current information.

What Is Advantame?

Advantame is a non-nutritive sweetener derived from aspartame and isovanillin, providing approximately 20,000 times the sweetness of sucrose — making it one of the most potent approved sweeteners. Unlike aspartame, it does not require PKU labeling at approved use levels because the amount of phenylalanine released per serving is negligible. JECFA established an ADI of 5 mg/kg body weight. EFSA reviewed advantame in 2013 and confirmed safety. Approved in EU (2014), USA (2014), Australia/NZ, and Japan for use in a range of food and beverage applications.

? Did You Know?

Beyond food, Advantame is also used in medicine, industrial applications. Its versatility makes it one of the most multi-purpose chemical compounds in everyday life.

To reach the Acceptable Daily Intake limit, a 60kg adult would need to consume approximately ~1,667 cans of advantame-sweetened beverage (355ml) in a single day. (This is a mathematical illustration, not a safety recommendation.)

Advantame is fully synthetic — it doesn't exist in nature and is manufactured entirely through chemical processes.

Detailed Regulatory Assessment

🇪🇺

European Union (EFSA)

approved Max: varies by food category (0.5-5 mg/kg) mg/kg

Extremely low maximum levels due to ultra-high sweetness intensity

Official EFSA Link

🇺🇸

United States (FDA)

approved Approved food additive

Approved in 2014; no PKU warning required

🇯🇵

Japan (MHLW)

approved Cat: 指定添加物

Approved with extremely low maximum use levels

Acceptable Daily Intake (ADI)

International Standard (JECFA)

0–5 mg/kg bw/day

mg/kg body weight per day

European Standard (EFSA)

5 mg/kg bw/day

Everyday Perspective

For a 60kg adult, this limit is roughly equivalent to consuming:

~1,667 of cans of advantame-sweetened beverage (355ml)

~0.18mg per serving

~6,000 of pieces of advantame-sweetened gum

~0.05mg per serving

Natural Occurrence

This additive is not known to occur naturally in significant quantities.

Manufacturing

Method: chemical synthesis

Synthesized from aspartame and vanillin through a multi-step chemical process. The resulting compound is significantly more potent than its parent molecule aspartame.

Applications Beyond Food

Medical

Potential use in medications

Industrial

Flavor enhancer

Frequently Asked Questions

What is Advantame (E969)?

Advantame (E969) is a sweetener used in food products. It is artificial and synthetic. The newest and most potent artificial sweetener approved globally. About 20,000-37,000 times sweeter than sucrose. Derived from aspartame but does not require PKU warning. Extremely heat-stable.

What is the ADI for Advantame?

The Acceptable Daily Intake (ADI) for Advantame is 0–5 mg/kg bw/day as established by JECFA (Joint FAO/WHO Expert Committee on Food Additives). ADI represents the amount that can be consumed daily over a lifetime without appreciable health risk.

What foods contain Advantame?

Advantame is used in various food categories including Other non-alcoholic beverages, Confectionery. It is used as a sweetener in these products.