Disclaimer: This database provides factual regulatory information compiled from official government sources. It does not constitute medical, nutritional, or safety advice. Regulatory status varies by country and may change. Always refer to your local regulatory authority for the most current information.
Regulatory History: Monosodium Glutamate
E621 — Complete timeline of regulatory events
About This Timeline
This page documents the regulatory history of Monosodium Glutamate (E621), including approvals, bans, safety evaluations, and classification changes by regulatory agencies worldwide.
Data source: Official regulatory documents, scientific publications, and agency announcements. All events are documented with source agencies and dates.
Complete Timeline
9 eventsJapanese chemist Kikunae Ikeda isolated glutamic acid from kombu seaweed and identified umami as the fifth basic taste.
MSG commercially produced and marketed in Japan as 'Ajinomoto' (essence of taste).
Dr. Kwok published letter in New England Journal of Medicine describing symptoms after eating at Chinese restaurants, coining term 'Chinese Restaurant Syndrome'.
Animal studies suggested possible neurotoxic effects at very high doses, sparking public concern.
Federation of American Societies for Experimental Biology (FASEB) conducted review, found MSG safe for most people.
JECFA placed MSG in safest category for food additives, with ADI 'not specified' meaning no safety concerns at current use levels.
FDA commissioned comprehensive report by FASEB, concluded MSG is safe for general population. Acknowledged small percentage may have short-term reactions.
EFSA re-evaluated glutamic acid and glutamates (E620-E625), concluded no safety concern at current use and exposure levels.
Growing recognition that term 'Chinese Restaurant Syndrome' is misleading and potentially racist. Medical community moving away from the term.
Important Notes
- This timeline is for informational purposes only and does not constitute safety advice.
- Regulatory decisions reflect the state of scientific knowledge at the time they were made.
- Current regulations may differ from historical events shown. Always consult official sources for up-to-date information.
- An approval in one country does not imply approval in others. Regulatory standards vary by jurisdiction.