Disclaimer: This database provides factual regulatory information compiled from official government sources. It does not constitute medical, nutritional, or safety advice. Regulatory status varies by country and may change. Always refer to your local regulatory authority for the most current information.
Regulatory History: Cyclamate
E952 — Complete timeline of regulatory events
About This Timeline
This page documents the regulatory history of Cyclamate (E952), including approvals, bans, safety evaluations, and classification changes by regulatory agencies worldwide.
Data source: Official regulatory documents, scientific publications, and agency announcements. All events are documented with source agencies and dates.
Complete Timeline
9 eventsCyclamate discovered accidentally by graduate student Michael Sveda at University of Illinois.
FDA approved cyclamate as GRAS (Generally Recognized As Safe) sweetener.
Studies suggested that cyclamate combined with saccharin may cause bladder cancer in laboratory rats.
FDA banned cyclamate in the USA under Delaney Clause due to cancer concerns in animal studies.
JECFA established ADI of 0-11 mg/kg bw/day, concluded cyclamate is safe at this level.
Cyclamate approved as E952 in the EU with maximum use levels specified.
Scientific Committee on Food re-evaluated cyclamate, confirmed ADI of 7 mg/kg bw/day (lower than JECFA).
EFSA re-evaluated cyclamate and cyclamic acid (E952), maintained previous safety conclusions and ADI.
Cyclamate remains banned in USA despite multiple petitions for re-approval and approval in many other countries.
Important Notes
- This timeline is for informational purposes only and does not constitute safety advice.
- Regulatory decisions reflect the state of scientific knowledge at the time they were made.
- Current regulations may differ from historical events shown. Always consult official sources for up-to-date information.
- An approval in one country does not imply approval in others. Regulatory standards vary by jurisdiction.