Hydroxypropyl Cellulose E463
emulsifier, stabilizer, film-former, coating agent — Primarily natural (modified).
Hydroxypropylcellulose
CAS: 9004-64-2
Factual Regulatory Reference
This database provides factual regulatory information compiled from official government sources. It does not constitute medical, nutritional, or safety advice. Regulatory status varies by country and is subject to change. Always refer to your local regulatory authority for the most current information.
What Is Hydroxypropyl Cellulose?
Hydroxypropyl cellulose (HPC) is a cellulose ether that dissolves in cold water to form clear, viscous solutions. It functions as a thickener, film-forming agent, and stabilizer in a range of food applications. HPC has thermoplastic properties and can form films at elevated temperatures. JECFA considers it acceptable with no ADI specified. EFSA reviewed cellulose derivatives in 2016. HPC is also widely used in pharmaceutical applications including controlled-release drug delivery and ophthalmic preparations. Approved in the EU, USA, Japan, Canada, and Australia.
? Did You Know?
Hydroxypropyl Cellulose is derived from plant materials — its origin is more natural than its E-number might suggest.
Beyond food, Hydroxypropyl Cellulose is also used in cosmetics, medicine, industrial applications, household products. Its versatility makes it one of the most multi-purpose chemical compounds in everyday life.
Although classified as natural in origin, commercial Hydroxypropyl Cellulose is typically manufactured rather than extracted directly from food sources.
Detailed Regulatory Assessment
European Union (EFSA)
Widely permitted in most food categories; considered safe cellulose derivative.
United States (FDA)
Regulated as a direct food additive under FDA CFR titles.
Japan (MHLW)
Compliant with Japanese food sanitation law.
Acceptable Daily Intake (ADI)
International Standard (JECFA)
mg/kg body weight per day
European Standard (EFSA)
Natural Occurrence
This additive is not known to occur naturally in significant quantities.
Manufacturing
Produced by reacting alkali cellulose with propylene oxide, which adds hydroxypropyl groups to the cellulose backbone. The degree of substitution determines solubility and other properties. HPC is soluble in cold water and many organic solvents.
Applications Beyond Food
Thickener and film-former in lotions, creams, and hair products.
Tablet binder and film coating, controlled-release matrix, ophthalmic lubricant (artificial tears).
Coatings, ceramics, textiles, construction materials, paper sizing.
Paint additives, ceramic glazes.